DERIVATIVES OF 13(1)-N-{2-[N-(CLOSO-MONOCARBADODECABORAN-1-YL)- METHYL]AMINOETHYL}AMIDE-15(2),17(3)-DIMETHYL ETHER OF CHLORINE e6, MANIFESTING PROPERTIES OF PHOTOSENSITISER

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to derivatives of 13(l)-N-{2-N-(closo-monocarbadodecaboran-1-yl)-methyl]aminoethyl}amide-15(2), 17(3)-dimethyl ether of chlorine e6 of general formula ^ , where M=Cs, Na, manifesting properties of photosensitiser. ^ EFFECT: compounds can...

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Hauptverfasser:	KALININ VALERIJ NIKOLAEVICH, NIKITINA ROZA GAVRILOVNA, AGAPOV IGOR' IVANOVICH, OL'SHEVSKAJA VALENTINA ANTONOVNA, KAPLAN MIKHAIL ALEKSANDROVICH, ZAJTSEV ANDREJ VIKTOROVICH, MOJSENOVICH MIKHAIL MIKHAJLOVICH, RAMONOVA ALLA ALIKOVNA, SAVCHENKO ARINA NIKOLAEVNA, SHTIL' ALEKSANDR AL'BERTOVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to derivatives of 13(l)-N-{2-N-(closo-monocarbadodecaboran-1-yl)-methyl]aminoethyl}amide-15(2), 17(3)-dimethyl ether of chlorine e6 of general formula ^ , where M=Cs, Na, manifesting properties of photosensitiser. ^ EFFECT: compounds can be used in medicine as agents for boron neutron capture therapy (BNCT) and photodynamic therapy (FDT) of malignant neoplasms. ^ 2 ex, 1 tbl, 2 dwg Изобретение относится к производным 13(1)-N-{2-[N-(клозо-монокарбадодекаборан-1-ил)-метил]аминоэтил}амид-15(2),17(3)-диметилового эфира хлорина е6 общей формулы ! ! где M=Cs, Na, проявляющим свойства фотосенсибилизатора. Заявляемые соединения могут быть использованы в медицине в качестве агентов для борнейтронозахватной терапии (БНЗТ) и фотодинамической терапии (ФДТ) злокачественных новообразований. 1 табл., 2 ил.