BENZAMIDE AND HETEROARENE DERIVATIVES

FIELD: chemistry. ^ SUBSTANCE: present invention relates to novel compounds of formula I: , ^ to their synthesis method, a pharmaceutical composition based on said compounds and use of said compounds in making medicinal agents. Substitutes R1, R2, R4, R5, as well as values of A, B, D and n are given...

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Bibliographische Detailangaben
Hauptverfasser:	PFLIZHE FILIPP, MOZHE SIRILL, KJUNE KHOL'GER, LJUBBERS TOMAS, KONTE ORIL'JA, MATTEJ PATRITSIO, MJULLER VERNER
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: chemistry. ^ SUBSTANCE: present invention relates to novel compounds of formula I: , ^ to their synthesis method, a pharmaceutical composition based on said compounds and use of said compounds in making medicinal agents. Substitutes R1, R2, R4, R5, as well as values of A, B, D and n are given in the formula of invention. ^ EFFECT: obtaining novel compounds of formula I: , ^ as well as their pharmaceutically acceptable salts which have inhibitory effect on cholesteryl ester transfer protein (CETP). ^ 14 cl, 251 ex Настоящее изобретение относится к новым соединениям формулы I: ! , ! а также к их фармацевтически приемлемым солям, обладающим ингибирующей активностью в отношении белка-переносчика холестерилового эфира (БПХЭ), к способу их получения, фармацевтической композиции на их основе и к их применению для приготовления лекарственных средств. Значения заместителей R1, R2, R4, R5, а также А, В, D и n указаны в формуле изобретения. 4 н. и 10 з.п. ф-лы.