NEW PHTHALAZINONE DERIVATIVES AS AURORA A KINASE INHIBITORS

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: there are described compounds of formula I: , their pharmaceutically acceptable salts where R1-R7, Y and n are specified in the patent claim. The compounds exhibit inhibitory action in the relation to aurora A tyrosine kinase. There is also described a dr...

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Hauptverfasser:	RJUT MATTIAS, ZHORZH GI, BOJD EHDUARD, BRUKFILD FREDERIK, GOLLER BERNKHARD, KHJUNSH ZABINE, FON-DER-ZAL VOL'FGANG, VAJGAND SHTEFAN, SHJULL' KRISTINE, UORN DZHASTIN, SHAJBLIKH SHTEFAN, RJUGER PETRA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: medicine, pharmaceutics. ^ SUBSTANCE: there are described compounds of formula I: , their pharmaceutically acceptable salts where R1-R7, Y and n are specified in the patent claim. The compounds exhibit inhibitory action in the relation to aurora A tyrosine kinase. There is also described a drug of the compound of formula (I). The drug can be used for control or prevention of diseases, such as cancer. ^ EFFECT: preparation of new phthalazinone derivatives which can be used for control or prevention of diseases, such as cancer. ^ 17 cl, 2 tbl, 41 ex Описываются соединения формулы I: ! ! их фармацевтически приемлемые соли, где R1-R7, Y и n указаны в формуле изобретения. Соединения обладают ингибирующим действием в отношении тирозинкиназы аврора А. Описывается также лекарственное средство на основе соединения формулы (I). Средство может использоваться для контроля или профилактики заболеваний, таких как рак. 2 н. и 15 з.п. ф-лы, 2 табл.