INACTIVATED COMBINED VACCINE AGAINST CATTLE INFECTIOUS RHINOTRACHEITIS, VIRUS DIARRHOEA AND LEPTOSPIROSIS

FIELD: medicine. ^ SUBSTANCE: invention refers to biotechnology. The vaccine contains an active substance and target additives. The active substance is presented with mixed inactivated viral suspension of cattle infectious rhinotracheitis virus strain, SVC (State Virus Collection) No. 2333, Herpesviridae family, Alphaherpesviridae subfamily, inactivated viral suspension of cattle diarrhoea virus strain SVC No. 2336, Flaviviridae family, Pestivirus genus with activity of each strain not less than 107.0 "ö50" per 1 cm3 of the vaccine. As said active substance, the vaccine also contains mixed inactivated suspension of Leptospira interrogans bacteria cells of Pomona serogroup of strain VGNKI-6, inactivated suspension of Leptospira interrogans bacteria cells of Tarassovi serogroup of strain VGNKI-4, inactivated suspension of Leptospira interrogans bacteria cells of Grippotyphosa serogroup of strain VGNKI-1, inactivated suspension of Leptospira interrogans bacteria cells of Sejroe serogroup of Hardjo strain and inaktivirovannoj suspensions of cells of bacteria Leptospira interrogans of Sejroe serogroup of strain VGNKI-5 taken in the ratio equal to final concentration of each Leptospira strain not less than 270 million microbial cells per 1 cm3 of the vaccine. The vaccine is intended for prevention of cattle infectious diseases accompanied by reproductive disorders of various severities. ^ EFFECT: vaccine is better than common vaccines in the spectrum of specific protection and effectiveness for tolerant group of animals, duration of intense immunity, harmlessness for incalvers and newborn calves, stability of biological properties, including antigen and immunogen activity throughout 18 months (follow-up period). ^ 3 cl, 8 tbl, 6 ex Изобретение относится к области биотехнологии. Вакцина содержит активное вещество и целевые добавки. В качестве активного вещества она содержит смесь инактивированной вирусной суспензии штамма вируса инфекционного ринотрахеита крупного рогатого скота ГКВ №2333, семейства Herpesviridae, подсемейства Alphaherpesviridae, инактивированной вирусной суспензии штамма вируса диареи крупного рогатого скота ГКВ №2336, семейства Flaviviridae, рода Pestivirus, с активностью каждого из штаммов не менее 107,0 ТЦД50 в 1 см3 вакцины. Вакцина также содержит в качестве активного вещества смесь инактивированной суспензии клеток бактерий Leptospira interrogans серогруппы Pomona штамма ВГНКИ-6, инактивированной суспензии клеток бактерий Leptospira interro