1-PHENYL-2-DIMETHYLAMINOMETHYLCYCLOHEXANE COMPOUNDS FOR DEPRESSION TREATMENT AND PAIN MANAGEMENT

FIELD: medicine. ^ SUBSTANCE: invention refers to new compounds chosen from the group 3-(2-mono- or dimethylaminomethylcyclohexyl)phenol, chosen of the group including mono-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, mono-(1R,2R)-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, 3-(2-m...

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Hauptverfasser: SHTRASSBURGER VOL'FGANG, BUSHMANN KHEL'MUT, FRIDERIKHS EHL'MAR, EHNGL'BERGER VERNER, TSIMMER OSVAL'D, KHOLENTS JERG, ZAUNDERS DEREK, KHENNIZ KHAGEN-GENRIKH, JANEL' UL'RIKH
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: medicine. ^ SUBSTANCE: invention refers to new compounds chosen from the group 3-(2-mono- or dimethylaminomethylcyclohexyl)phenol, chosen of the group including mono-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, mono-(1R,2R)-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, 3-(2-methylaminomethylcyclogexyl)phenol, (1R,2R)-3-(2-methylaminomethylcyclogexyl)phenol, N-oxide 3-(2-dimethylaminomethylcyclogexyl)phenol, N-oxide (1R,2R)-3-(2-dimethylaminomethylcyclogexyl)phenol, 6-[3-(2-dimethylaminomethylcyclogexyl)phenoxy]-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid, 6-[(1R,2R)-3-(2-dimethylaminomethylcyclogexyl)phenoxy]-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid, 4-(2-dimethylaminomethylcyclogexyl)catechol, (1R,2R)-4-(2-dimethylaminomethylcyclogexyl)catechol, 3-(2-aminomethylcyclohexyl)phenol, (1R,2R)-3-(2-aminomethylcyclohexyl)phenol, C-[2-(3-methoxyphenyl)cyclogexyl]methylamine, (1R,2R)-C-[2-(3-methoxyphenyl)cyclogexyl]methylamine, [2-(3-methoxyphenyl) cyclohexylmethyl]methylamine, (1R,2R)-[2-(3-methoxyphenyl) cyclohexylmethyl]methylamine, N-oxide [2-(3-methoxyphenyl)cyclohexylmethyl]dimethylamine, and N-oxide (1R,2R)-[2-(3-methoxyphenyl)cyclohexylmethyl]dimethylamine, and also to application of the compounds for preparing a drug for treatment of depression which can be combined with pain, first of all acute visceral chronic or nephropathic pain and pain caused by cancer. ^ EFFECT: improved clinical effectiveness. ^ 6 cl, 3 dwg, 2 tbl, 14 ex Изобретение относится к новым соединениям, выбранным из группы 3-(2-моно- или диметиламинометилциклогексил)фенола, выбранным из группы, включающей моно-[3-(2-диметиламинометилциклогексил)фенил]эфир серной кислоты, моно-(1R,2R)-[3-(2-диметиламинометилциклогексил)фенил]эфир серной кислоты, 3-(2-метиламинометилциклогексил)фенол, (1R,2R)-3-(2-метиламинометилциклогексил)фенол, N-оксид 3-(2-диметиламинометилциклогексил)фенола, N-оксид (1R,2R)-3-(2-диметиламинометилциклогексил)фенола, 6-[3-(2-диметиламинометилциклогексил)фенокси]-3,4,5-тригидрокситетрагидропиран-2-карбоновую кислоту, 6-[(1R,2R)-3-(2-диметиламинометилциклогексил)фенокси]-3,4,5-тригидрокситетрагидропиран-2-карбоновую кислоту, 4-(2-диметиламинометилциклогексил)катехол, (1R,2R)-4-(2-диметиламинометилциклогексил)катехол, 3-(2-аминометилциклогексил)фенол, (1R,2R)-3-(2-аминометилциклогексил)фенол, С-[2-(3-метоксифенил)циклогексил]метиламин, (1R,2R)-С-[2-(3-метоксифенил)циклогексил]метиламин, [2-(3-метоксифенил)циклогексилметил]метиламин,