INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.01,5]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.01,5]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel intermediate compounds - methyl 7-aryl-4,9-diaroyl-3-hydroxy-1-(2-hydroxyphenyl)-2,6-dioxo-1,7-diazaspiro[4.4]none-3,8-diene-8-carboxylates of formula III Ar1=Ar2=Ph, Ar3=C6H4Me-n (IIIa); and Ar1=C6H4Br-n, Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IIIb), for synthesis of methyl 6,9-diaryl-11-aroyl-2-(o-hydroxyphenyl)-3,4,10-trioxo-7-oxa-2,9-diazatricyclo[6.2.1.01,5]undec-6-ene-8-carboxylates of formula IV where Ar1=Ar2=Ph, Ar3=C6H4Me-n (IVa); Ar1=C6H4Br-n Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IVb), which exhibit antimicrobial activity and are used as precursors for synthesis of novel heterocyclic systems, and a method for synthesis of said compounds. ^ EFFECT: compounds have high effectiveness. ^ 5 cl, 1 tbl, 5 ex Изобретение относится к новым промежуточным соединениям - метил ! 7-арил-4,9-диароил-3-гидрокси-1-(2-гидроксифенил)-2,6-диоксо-1,7-диазаспиро[4.4]нона-3,8-диен-8-карбоксилатам формулы III ! ! Ar1=Ar2=Ph, Ar3=C6H4Me-п (IIIa); и Ar1=C6H4Br-п, Аr2=С6H4ОЕt-п, Ar3=C6H4Me-п (IIIб), для получения метил 6,9-диарил-11-ароил-2-(о-гидpoкcифeнил)-3,4,10-тpиoкco-7-oкca-2,9-диaзaтpициклo[6.2.1.01,5]ундeц-6-ен-8-карбоксилатов формулы IV ! ! где Ar1=Ar2=Ph, Ar3=C6H4Me-п (IVa); Arl=C6H4Br-п Ar2=C6H4OEt-п, Аr3=С6Н4Ме-п (IVб), проявляющих противомикробную активность и используемых в качестве исходных продуктов для синтеза новых гетероциклических систем, и способу их получения. 4 н. и 1 з.п. ф-лы, 1 табл.