SPIROCYCLIC DERIVATIVES OF CYCLOHEXANE WITH AFFINITY TO ORL1 RECEPTOR

FIELD: chemistry. ^ SUBSTANCE: described are spirocyclic derivatives of cyclohexane of general formula . Values of radicals are given in the formula of invention. The compounds have affinity to the ORL1 receptor and can be used for treating abstinence syndrome (withdrawal syndrome) and pain. Also de...

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Hauptverfasser:	MERLA BEATRIKS, OBERBERSH SHTEFAN, SHREDER VOL'FGANG, FRIDERIKHS EHL'MAR, SHIKK KHANS, EHNGL'BERGER VERNER, KEGEL' BABETTE-IVONNE, KHENKEL' BIRGITTA, DERMANN BERND, KHINTSE KLAUDIA, FRORMANN SVEN, LINTS KLAUS, ZAUNDERS DEREK
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: chemistry. ^ SUBSTANCE: described are spirocyclic derivatives of cyclohexane of general formula . Values of radicals are given in the formula of invention. The compounds have affinity to the ORL1 receptor and can be used for treating abstinence syndrome (withdrawal syndrome) and pain. Also described is a medicinal agent and use of formula (I) compounds for preparing respective medicinal agents. ^ EFFECT: increased effectiveness of using the compounds. ^ 13 cl, 17 ex, 1 dwg Описаны спироциклические производные циклогексана общей формулы (I), значения радикалов указаны в формуле изобретения. Соединения обладают сродством к ORL1-рецептору и могут быть использованы для лечения абстиненции (синдрома отмены) или боли. Описаны также лекарственное средство и применение соединения формулы (I) для получения соответствующих лекарственных средств. 8 н. и 5 з.п. ф-лы, 1 ил., 2 табл.