NOVEL PYRAZOLOPYRIMIDINES AS INHIBITORS OF CYCLIN-DEPENDANT KINASE

FIELD: chemistry. ^ SUBSTANCE: described are novel derivatives of pyrazolo[1,5-a]pyrimidine with general formula 1 (values of radicals are given in the formula of invention), a pharmaceutical composition containing said derivatives and use of the novel compounds for preparing a medicinal agent for t...

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Hauptverfasser: KIRTIKAR KARTIK M, PARADKAR VID'JADKHAR M, PARUCH KAMIL, CHAN TIN-JAU, DVAJER MAJKL P, FISHMANN T'ERRI O, DOLL RONAL'D DZH, RIVERA ZHOSELIN, AL'VARES KARMEN S, KHE ZHEN MIN, GUZI TIMOTI DZH, KHOBBS DUGLAS UOLSH, MEHDISON VINSENT, TRAN VIN D, MEHLLEHMS ALAN, PARK KHEHNGSUN, GIRIJAVALLABKHAN VIJUR MUPIL, DILLARD LOURENS V, DZHEHJMS REHJ EHNTONI
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: chemistry. ^ SUBSTANCE: described are novel derivatives of pyrazolo[1,5-a]pyrimidine with general formula 1 (values of radicals are given in the formula of invention), a pharmaceutical composition containing said derivatives and use of the novel compounds for preparing a medicinal agent for treating one or more diseases associated with cyclin-dependant kinalse CDK2. ^ EFFECT: novel compounds have useful biological properties. ^ 36 cl, 87 tbl, 607 ex Описываются новые производные пиразоло[1,5-а]пиримидина общей формулы 1 ! ! (значения радикалов приведены в формуле изобретения), фармацевтическая композиция, их содержащая, и применение новых соединений для приготовления лекарственного средства для лечения одного или более заболеваний, связанных с циклин-зависимой киназой CDK2. ! 3 н. и 33 з.п. ф-лы, 87 табл.