NEW ISOINDOLE DERIVATIVES, COMPOSITIONS CONTAINING THEREOF, PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF, PARTICULARLY AS INHIBITORS OF CHAPERONE PROTEIN Hsp90 ACTIVITY

NEW ISOINDOLE DERIVATIVES, COMPOSITIONS CONTAINING THEREOF, PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF, PARTICULARLY AS INHIBITORS OF CHAPERONE PROTEIN Hsp90 ACTIVITY

FIELD: medicine. ^ SUBSTANCE: there are described new isoindole derivatives of general formula (1), wherein A1, A2 and A4 stands for CH, and A3 means N or C-OH; n is equal to 2; R1 represents O; R2-stands for H; and a pharmaceutical composition containing thereof. ^ EFFECT: new compounds are inhibit...

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Bibliographische Detailangaben
Hauptverfasser: BERTEHN LJUK, VALLE FRANSUA, KARRE SHANTAL, MAJLIE PATRIK, BAK EHRIK, BENAR DID'E
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: medicine. ^ SUBSTANCE: there are described new isoindole derivatives of general formula (1), wherein A1, A2 and A4 stands for CH, and A3 means N or C-OH; n is equal to 2; R1 represents O; R2-stands for H; and a pharmaceutical composition containing thereof. ^ EFFECT: new compounds are inhibitors of chaperone protein Hsp90 activity and can be used in chemotherapy of cancerous diseases. ^ 6 cl, 3 ex Описываются новые производные изоиндола общей формулы (I), ! ! в которой А1, А2 и А4 обозначает СН, а A3 обозначает N или С-ОН; n равно 2; R1 представляет собой О; R2 обозначает Н; и фармацевтическая композиция, их содержащая. Новые соединения являются ингибиторами активности белка-шаперона Hsp90 и могут быть использованы при химиотерапии раковых заболеваний. 2 н. и 4 з.п. ф-лы.