2,4-PYRIMIDINDIAMINE COMPOUNDS HAVING EFFECT IN CASE OF AUTOIMMUNE DISORDERS

FIELD: pharmacology. ^ SUBSTANCE: claimed invention relates to novel 2,4-pyridindiamine compounds of formula (1). In structural formula (I) L1 is direct bond; L2 is direct bond; R2 is phenyl group, three times substituted with three groups R8; R4 is X represents N; Y is selected from group consisting of O, NH, S, SO and SO2; Z is selected from group consisting of O, NH; on condition that if Y is selected from group consisting of NH, S, SO and SO2, Z is not the same as Y; R5 is selected from group consisting from R6, halogen; each R6 is independently selected from group consisting of hydrogen, halogen; R8 is selected from group consisting from Ra, Rb, Ra substituted with one or several similar or different groups Ra or Rb, -ORa, -O-CHRaRb; each R35 independently on others is selected from group consisting of hydrogen and R35, or in alternative case, two groups R35, bound to one and the same carbon atom are taken together with formation of oxogroup (=O), and the remaining two groups R35 each independently on each other are selected from group consisting from hydrogen and R8; each Ra is independently selected from group consisting of hydrogen, (C1-C6) alkyl, (C3-C8) cycloalkyl; each Rb is suitable group which is independently selected from group consisting of -ORd, halogen, -CF3, -C(O)NRcRc, and -OC(O)ORd; each Rc is independently protective group or Ra; each Rd is independently protective group or Ra; each index m is independently integer number from 1 to 3. ^ EFFECT: novel compounds can be used for treatment or prevention of autoimmune diseases, for instance such as rheumatoid arthritis and/or related to it symptoms, systemic lupus erythematosus and/or related to it symptoms, as well as and/or related to it symptoms. ^ 41 cl, 14 dwg, 1 ex Настоящее изобретение относится к новым соединениям 2,4-пиримидиндиамина формулы (I), которые могут быть использованы для лечения или профилактики аутоиммунных болезней, например, таких как ревматоидный артрит и/или связанные с ним симптомы, системная эритематозная волчанка и/или связанные с ней симптомы, а также рассеянный склероз и/или связанные с ним симптомы. В структурной формуле (I) ! ! L1 является прямой связью; L2 является прямой связью; R2 является фенильной группой, трижды замещенной тремя группами R8; R4 является ! Х представляет собой N; Y выбирается из группы, состоящей из О, NH, S, SO и SO2; Z выбирается из группы, состоящей из О, NH; при условии если Y выбран из группы, состоящей из NH, S, SO и SO2, то Z не