PYRIMIDINE COMPOUNDS WITH SELECTIVE INHIBITION OF "¦-¦" AND "L¦L¦" ACTIVITY

FIELD: chemistry; pharmacology. ^ SUBSTANCE: invention refers to new pyrimidine compounds of formula (I) with selective inhibition of "" and "" kinase. These compounds and their pharmaceutically acceptable salts are antiproliferative agents. In formula (I) , where R1 is chosen from series including -H, -(CH2)n -5-6-merous heterocycle containing 1-2 heteroatoms chosen from nitrogen, sulphur oxygen or dioxide, (C1-C6)alkyl, (C3-C6)cycloalkyl where n stands for 0, and each groups including heterocycle, alkyl, cycloalkyl is independently optionally substituted to three groups chosen from: -OR9, -COR10, -CO2R10, -CONR10R11 and -CN; R2 stands for -H or -OCH3; R3 stands for -H, -F or -OCH3; R4, R5 and R7 stand for -H, R6 means (C1-C6)alkyl or OR12; R8 stands for -H or -F; R9 stands for -H and (C1-C6)alkyl, (C1-C6)alkoxide R10 and R11 independently are chosen from -H and (C1-C6)alkyl, (C1-C6)alkoxy, and R12 stands for -H and (C1-C6)alkyl. ^ EFFECT: can be used for treating and preventing solid cancers, specifically breast, rectum, lung and prostate cancer.