BENZOFURAN AND BENZOTHIOPHEN DERIVATIVES APPLIED FOR HYPERPROLIFERATIVE DISEASE TREATMENT

FIELD: chemistry; pharmacology. ^ SUBSTANCE: invention refers to new benzofuran and benzothiophen derivatives of general formula I, , wherein X is chosen from O and S; R1 is chosen from H, (C1-C6)alkyl, C(O)(C1-C6) alkyl and benzoyl; R2 is chosen from phenyl optionally substituted with 1 or 2 substi...

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Bibliographische Detailangaben
Hauptverfasser:	DZHONS BENZHAMIN D, DJUMA ZHAK, ZHANG CHENGZHI, BERK MAJKL, FEHN DONGPING, LADUSER GAEHTAN, FILLIPS BARTON, KHATUM-MOKDAD KHOLIA, CHEN ZHI, FEHN JANMEJ, LI VENDI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HAULING HETEROCYCLIC COMPOUNDS HOISTING HOISTING, LIFTING, HAULING OR PUSHING, NOT OTHERWISE PROVIDEDFOR, e.g. DEVICES WHICH APPLY A LIFTING OR PUSHING FORCEDIRECTLY TO THE SURFACE OF A LOAD HUMAN NECESSITIES HYGIENE LIFTING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	FIELD: chemistry; pharmacology. ^ SUBSTANCE: invention refers to new benzofuran and benzothiophen derivatives of general formula I, , wherein X is chosen from O and S; R1 is chosen from H, (C1-C6)alkyl, C(O)(C1-C6) alkyl and benzoyl; R2 is chosen from phenyl optionally substituted with 1 or 2 substitutes, each independently chosen from CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy, halogen, halogen(C1-C6)alkyl, pyridyl or benzo[1,3]dioxolyl optionally substituted with (C1-C6)alkyl. There are disclosed pharmaceutical composition based on compounds I and method of treatment. ^ EFFECT: compounds can be used to treat or prevent diseases associated with malignant cell proliferation. ^ 26 cl, 7 tbl, 365 ex