VOLTAMPEROMETRIC METHOD FOR QUANTITATIVE LIDOCAINE HYDROCHLORIDE ASSAY

FIELD: chemistry. ^ SUBSTANCE: invention concerns analytical chemistry, particularly voltamperometric methods for medicine assay. Claimed voltamperic method of lidocaine hydrochloride [(2-diethylamine)-N(2,6-dimethylphenyl)acetamide in hydrochloride form] assay involves electrochemical concentration...

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Hauptverfasser:	EVTUKHOVA ELENA NIKOLAEVNA, PASHKOVA LESJA VLADIMIROVNA, BADAZHKOVA INNA EVGEN'EVNA, VOVCHENKO IRINA ALEKSEEVNA, IVANOVSKAJA ELENA ALEKSEEVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	FIELD: chemistry. ^ SUBSTANCE: invention concerns analytical chemistry, particularly voltamperometric methods for medicine assay. Claimed voltamperic method of lidocaine hydrochloride [(2-diethylamine)-N(2,6-dimethylphenyl)acetamide in hydrochloride form] assay involves electrochemical concentration of lidocaine hydrochloride on the surface of mercury film electrode for 32 s at electrolysis potential of (-1.3)V in 0.01 mol/l of potassium hydroxide solution, followed by registration of anode voltamperic curves at direct current potential scan speed of 55 mV/s and determination of lidocaine hydrochloride concentration by peak height at (-0.6)V potential against silver chloride electrode. Claimed method enhances assay sensitivity (10-5 - 10-9 mg/ml) and rapidity (single assay takes not more than 10 minutes). ^ EFFECT: enhanced assay sensitivity and rapidity. ^ 2 ex, 6 tbl