METHOD OF VALSARTAN OBTAINMENT

METHOD OF VALSARTAN OBTAINMENT

FIELD: chemistry. ^ SUBSTANCE: compound of general formula IIa or its salt, where R1 is hydrogen or protection group of tetrazol, undergoes reaction with compound of formula or its salt, where R2 is hydrogen or carboxy protection group, under conditions of reduction amination, with further acylation...

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Bibliographische Detailangaben
Hauptverfasser: DENNI-DISHER DONAS'ENN, SHNIDER ANITA, DERR'EN NADIN, KAUFMANN DANIEL, KHIRT KHANS, ZEDEL'MAJER GOTTFRID, NEVILLE DAN
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:FIELD: chemistry. ^ SUBSTANCE: compound of general formula IIa or its salt, where R1 is hydrogen or protection group of tetrazol, undergoes reaction with compound of formula or its salt, where R2 is hydrogen or carboxy protection group, under conditions of reduction amination, with further acylation of obtained compound of formula or its salt by compound of formula , where R3 is the group to be separated; and with removal of protection groups if required. ^ EFFECT: new compounds with useful biological properties. ^ 12 cl, 11 ex