PROPANE-1,3-DIONE DERIVATIVE AND ITS SALT

FIELD: chemistry. ^ SUBSTANCE: description is given of a derivative of propane-1,3-dione with general formula (I) and its pharmaceutical salt, in which symbols denote the following: ring A: benzol, which can be substituted, pyridine, which can be substituted or a thiophene ring; ring B: benzene or thiophene ring; R1: H or -CO-inferior alkyl; R2: H, -O-R5, -N(R6)R7, -N3, -S(O)m-inferior alkyl, pyridyl or imidazole, which can be substituted; R3: H or inferior alkyl; X: a bond, inferior alkylene, which can be substituted, or cycloalkanediyl. Description is also given of propane-1,3-dione derivatives with formulae (Ia) and (Ib) and a pharmaceutical composition. The proposed compounds are useful as GnRH receptor antagonists, can be used in curing diseases, which depend on sex hormones, such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma and non-malignant hypertrophy of the prostate gland. ^ EFFECT: obtaining compounds, useful for curing diseases, which depend on sex hormones, such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma and non-malignant hypertrophy of the prostate gland. ^ 10 cl, 26 tbl, 23 ex