OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT
FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to obtaining oxaliplatin used in tumor treatment, with low content of accompanying admixtures formed while obtaining it. Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005%...
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| creator | ZHAK FRANTISHEK CHAJKA-POULOVA ANNA |
| description | FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to obtaining oxaliplatin used in tumor treatment, with low content of accompanying admixtures formed while obtaining it. Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005% and nitrates not more than 0.01%. Method of obtaining lies in the following: suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N'] platinum (II) in water is processed with silver nitrate with molar ratio of complex compound to silver nitrate 1: |
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Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005% and nitrates not more than 0.01%. Method of obtaining lies in the following: suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N'] platinum (II) in water is processed with silver nitrate with molar ratio of complex compound to silver nitrate 1: <= 2, then, after removal of solid phase, obtained solution is processed with quaternary ammonium iodide of formula (R)4NI, where R independently represents hydrogen atom, possibly substituted aliphatic or cycloaliphatic radical, on condition that, at least, one of symbols R does not represent hydrogen atom, isolated solid phase is removed and obtained solution is processed with oxalic acid, and separated oxaliplatin is isolated, washed with water and polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture and dried. ^ EFFECT: obtaining oxaliplatin with low content of admixtures, suitable for obtaining pharmaceutical preparation. ^ 2 cl, 1 ex</description><language>eng ; rus</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090127&DB=EPODOC&CC=RU&NR=2345085C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090127&DB=EPODOC&CC=RU&NR=2345085C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHAK FRANTISHEK</creatorcontrib><creatorcontrib>CHAJKA-POULOVA ANNA</creatorcontrib><title>OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT</title><description>FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to obtaining oxaliplatin used in tumor treatment, with low content of accompanying admixtures formed while obtaining it. Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005% and nitrates not more than 0.01%. Method of obtaining lies in the following: suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N'] platinum (II) in water is processed with silver nitrate with molar ratio of complex compound to silver nitrate 1: <= 2, then, after removal of solid phase, obtained solution is processed with quaternary ammonium iodide of formula (R)4NI, where R independently represents hydrogen atom, possibly substituted aliphatic or cycloaliphatic radical, on condition that, at least, one of symbols R does not represent hydrogen atom, isolated solid phase is removed and obtained solution is processed with oxalic acid, and separated oxaliplatin is isolated, washed with water and polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture and dried. ^ EFFECT: obtaining oxaliplatin with low content of admixtures, suitable for obtaining pharmaceutical preparation. ^ 2 cl, 1 ex</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNysEKgkAQANC9dIjqH-YHgtCErtPu2g6sM2Ij2kkktlOUYP9PCH1Ap3d5a9NIj5HqiEoMHWmAKB1YYfWsICWgtVLVyDfiC6CrqNe28VdAdlB5DeKWJWdF4qWQbs3qMT7ntPu5MVB6tWGfpveQ5mm8p1f6DE2b5cficCpslv9RvogRL2Q</recordid><startdate>20090127</startdate><enddate>20090127</enddate><creator>ZHAK FRANTISHEK</creator><creator>CHAJKA-POULOVA ANNA</creator><scope>EVB</scope></search><sort><creationdate>20090127</creationdate><title>OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT</title><author>ZHAK FRANTISHEK ; CHAJKA-POULOVA ANNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2345085C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2009</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHAK FRANTISHEK</creatorcontrib><creatorcontrib>CHAJKA-POULOVA ANNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHAK FRANTISHEK</au><au>CHAJKA-POULOVA ANNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT</title><date>2009-01-27</date><risdate>2009</risdate><abstract>FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to obtaining oxaliplatin used in tumor treatment, with low content of accompanying admixtures formed while obtaining it. Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005% and nitrates not more than 0.01%. Method of obtaining lies in the following: suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N'] platinum (II) in water is processed with silver nitrate with molar ratio of complex compound to silver nitrate 1: <= 2, then, after removal of solid phase, obtained solution is processed with quaternary ammonium iodide of formula (R)4NI, where R independently represents hydrogen atom, possibly substituted aliphatic or cycloaliphatic radical, on condition that, at least, one of symbols R does not represent hydrogen atom, isolated solid phase is removed and obtained solution is processed with oxalic acid, and separated oxaliplatin is isolated, washed with water and polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture and dried. ^ EFFECT: obtaining oxaliplatin with low content of admixtures, suitable for obtaining pharmaceutical preparation. ^ 2 cl, 1 ex</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT |
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