BENZYLPYRIDAZINONES AS INHIBITORS OF REVERSE TRANSCRIPTASE

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns bonds, applicable for treatment of diseases mediated by the HIV virus, formula I where X1 is chosen from R5O, R5S(O)n, R5CH2, R5CH2O, R5CH2S(O)n, R5OCH2 and R5S(O)nCH2; R1 and R2 are chosen from H, NH2, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, halogen, alkylamino, dialkylamino, nitro and cyano; or in common form-CH=CH-CH=CH- or five-term heterocycle with the heteroatom chosen from O and S; R3 is chosen from H, halogen, nitro and cyano; R4 is chosen from H, NH2, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, halogen, alkylamino, dialkylamino, nitro and cyano; R5 the pyridine-N-oxide, indole, chinoline, chinoline-N-oxide is chosen from alkyl, cycloalkyl and unessentially replaced phenyl, naphthyl, pyridinil; R7 and R8 are chosen from H, NH2, an alkylamin, dialkylamine and unessentially substituted C1-C6alkyl; n is chosen from 0, 1, 2. ^ EFFECT: obtaining of new inhibitors by reverse transcriptase. ^ 2 cl, 46 ex, 3 tbl