3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group in...
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| creator | FERREJRA JOKHAN A JU JUNONG MERRITT DZH. ROUBERT DVAJER MAJKL CHAO JANPING NELSON KINGSLI KH EHJKI SINTIJA DZH BOLDVIN DZHON DZH TEJVRES ARTUR DZH LAJ DZHI BOND RICHARD V CHAO JANKHUA ROKOS LORA L KEJZER BERND |
| description | FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group including ^ ^ . The bonds can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and a cancer. The pharmaceutical composition and application of bonds I are also described. ^ EFFECT: obtaining of bonds which can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and cancer. ^ 50 cl, 31 ex
Настоящее изобретение относится к 3,4-дизамещенным циклобутен-1,2-дионам формулы I ! ! или их фармацевтически приемлемым солям или сольватам, ! где А выбран из группы, включающей ! ! ! X=-O-, -NH-, -S-, ! ! n=1-5 ! В выбран из группы, включающей ! ! ! Соединения могут быть использованы при лечении опосредуемых хемокинами заболеваний, таких как острые и хронические воспалительные заболевания и рак. Описаны также фармацевтическая композиция и применение соединений I. 5 н. и 45 з.п. ф-лы. |
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Настоящее изобретение относится к 3,4-дизамещенным циклобутен-1,2-дионам формулы I ! ! или их фармацевтически приемлемым солям или сольватам, ! где А выбран из группы, включающей ! ! ! X=-O-, -NH-, -S-, ! ! n=1-5 ! В выбран из группы, включающей ! ! ! Соединения могут быть использованы при лечении опосредуемых хемокинами заболеваний, таких как острые и хронические воспалительные заболевания и рак. Описаны также фармацевтическая композиция и применение соединений I. 5 н. и 45 з.п. ф-лы.</description><language>eng ; rus</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090520&DB=EPODOC&CC=RU&NR=2344123C9$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090520&DB=EPODOC&CC=RU&NR=2344123C9$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FERREJRA JOKHAN A</creatorcontrib><creatorcontrib>JU JUNONG</creatorcontrib><creatorcontrib>MERRITT DZH. ROUBERT</creatorcontrib><creatorcontrib>DVAJER MAJKL</creatorcontrib><creatorcontrib>CHAO JANPING</creatorcontrib><creatorcontrib>NELSON KINGSLI KH</creatorcontrib><creatorcontrib>EHJKI SINTIJA DZH</creatorcontrib><creatorcontrib>BOLDVIN DZHON DZH</creatorcontrib><creatorcontrib>TEJVRES ARTUR DZH</creatorcontrib><creatorcontrib>LAJ DZHI</creatorcontrib><creatorcontrib>BOND RICHARD V</creatorcontrib><creatorcontrib>CHAO JANKHUA</creatorcontrib><creatorcontrib>ROKOS LORA L</creatorcontrib><creatorcontrib>KEJZER BERND</creatorcontrib><title>3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR</title><description>FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group including ^ ^ . The bonds can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and a cancer. The pharmaceutical composition and application of bonds I are also described. ^ EFFECT: obtaining of bonds which can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and cancer. ^ 50 cl, 31 ex
Настоящее изобретение относится к 3,4-дизамещенным циклобутен-1,2-дионам формулы I ! ! или их фармацевтически приемлемым солям или сольватам, ! где А выбран из группы, включающей ! ! ! X=-O-, -NH-, -S-, ! ! n=1-5 ! В выбран из группы, включающей ! ! ! Соединения могут быть использованы при лечении опосредуемых хемокинами заболеваний, таких как острые и хронические воспалительные заболевания и рак. Описаны также фармацевтическая композиция и применение соединений I. 5 н. и 45 з.п. ф-лы.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPA11jHRdfEMDnUKDvEMCQ1xdVFwjnT28XcCMv1cdQ11jICy_n6uwQqOwQo-nu6Ofi7BCv5uCs4RzrrOHq6-_t6efq4KQa7OrgEh_kE8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSQ-KNTI2MTE0MjY2dKYCCUAT7EtfA</recordid><startdate>20090520</startdate><enddate>20090520</enddate><creator>FERREJRA JOKHAN A</creator><creator>JU JUNONG</creator><creator>MERRITT DZH. ROUBERT</creator><creator>DVAJER MAJKL</creator><creator>CHAO JANPING</creator><creator>NELSON KINGSLI KH</creator><creator>EHJKI SINTIJA DZH</creator><creator>BOLDVIN DZHON DZH</creator><creator>TEJVRES ARTUR DZH</creator><creator>LAJ DZHI</creator><creator>BOND RICHARD V</creator><creator>CHAO JANKHUA</creator><creator>ROKOS LORA L</creator><creator>KEJZER BERND</creator><scope>EVB</scope></search><sort><creationdate>20090520</creationdate><title>3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR</title><author>FERREJRA JOKHAN A ; JU JUNONG ; MERRITT DZH. ROUBERT ; DVAJER MAJKL ; CHAO JANPING ; NELSON KINGSLI KH ; EHJKI SINTIJA DZH ; BOLDVIN DZHON DZH ; TEJVRES ARTUR DZH ; LAJ DZHI ; BOND RICHARD V ; CHAO JANKHUA ; ROKOS LORA L ; KEJZER BERND</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2344123C93</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2009</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FERREJRA JOKHAN A</creatorcontrib><creatorcontrib>JU JUNONG</creatorcontrib><creatorcontrib>MERRITT DZH. ROUBERT</creatorcontrib><creatorcontrib>DVAJER MAJKL</creatorcontrib><creatorcontrib>CHAO JANPING</creatorcontrib><creatorcontrib>NELSON KINGSLI KH</creatorcontrib><creatorcontrib>EHJKI SINTIJA DZH</creatorcontrib><creatorcontrib>BOLDVIN DZHON DZH</creatorcontrib><creatorcontrib>TEJVRES ARTUR DZH</creatorcontrib><creatorcontrib>LAJ DZHI</creatorcontrib><creatorcontrib>BOND RICHARD V</creatorcontrib><creatorcontrib>CHAO JANKHUA</creatorcontrib><creatorcontrib>ROKOS LORA L</creatorcontrib><creatorcontrib>KEJZER BERND</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FERREJRA JOKHAN A</au><au>JU JUNONG</au><au>MERRITT DZH. ROUBERT</au><au>DVAJER MAJKL</au><au>CHAO JANPING</au><au>NELSON KINGSLI KH</au><au>EHJKI SINTIJA DZH</au><au>BOLDVIN DZHON DZH</au><au>TEJVRES ARTUR DZH</au><au>LAJ DZHI</au><au>BOND RICHARD V</au><au>CHAO JANKHUA</au><au>ROKOS LORA L</au><au>KEJZER BERND</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR</title><date>2009-05-20</date><risdate>2009</risdate><abstract>FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group including ^ ^ . The bonds can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and a cancer. The pharmaceutical composition and application of bonds I are also described. ^ EFFECT: obtaining of bonds which can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and cancer. ^ 50 cl, 31 ex
Настоящее изобретение относится к 3,4-дизамещенным циклобутен-1,2-дионам формулы I ! ! или их фармацевтически приемлемым солям или сольватам, ! где А выбран из группы, включающей ! ! ! X=-O-, -NH-, -S-, ! ! n=1-5 ! В выбран из группы, включающей ! ! ! Соединения могут быть использованы при лечении опосредуемых хемокинами заболеваний, таких как острые и хронические воспалительные заболевания и рак. Описаны также фармацевтическая композиция и применение соединений I. 5 н. и 45 з.п. ф-лы.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR |
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