3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR

3,4-DISUBSTITUTED CYCLOBUTENE-1,2-DIONES AS LIGANDS OF CXC-CHEMOKINE RECEPTOR

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group in...

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Hauptverfasser: FERREJRA JOKHAN A, JU JUNONG, MERRITT DZH. ROUBERT, DVAJER MAJKL, CHAO JANPING, NELSON KINGSLI KH, EHJKI SINTIJA DZH, BOLDVIN DZHON DZH, TEJVRES ARTUR DZH, LAJ DZHI, BOND RICHARD V, CHAO JANKHUA, ROKOS LORA L, KEJZER BERND
Format: Patent
Sprache:eng ; rus
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, . A is chosen from the group including ^ ^ X=-O-, -NH-, -S-, ^ . ^ n=1-5 ^ B is chosen from the group including ^ ^ . The bonds can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and a cancer. The pharmaceutical composition and application of bonds I are also described. ^ EFFECT: obtaining of bonds which can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and cancer. ^ 50 cl, 31 ex Настоящее изобретение относится к 3,4-дизамещенным циклобутен-1,2-дионам формулы I ! ! или их фармацевтически приемлемым солям или сольватам, ! где А выбран из группы, включающей ! ! ! X=-O-, -NH-, -S-, ! ! n=1-5 ! В выбран из группы, включающей ! ! ! Соединения могут быть использованы при лечении опосредуемых хемокинами заболеваний, таких как острые и хронические воспалительные заболевания и рак. Описаны также фармацевтическая композиция и применение соединений I. 5 н. и 45 з.п. ф-лы.