FLUORINE AND TRIFLUORALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA-AMYLOID FORMATION AND THEIR DERIVATIVES

FIELD: chemistry, pharmacology. ^ SUBSTANCE: claimed invention relates to fluorine and trifluoralkyl-containing heterocyclic sulfonamides of general formula I , where T - CHO, COR8 and C(OH)R1R2; R1 and R2 -hydrogen, C1-6alkyl; R3 -hydrogen; R4 - (CF3)nalkyl, (CF3)nalkylphenyl, and (F)ncycloalkyl; N equals 1-2; R5 - hydrogen, halogen, dien, condensed with Y, when Y stands for C, and dien, condensed with Y, when Y stands for C and substituted with halogen; W, Y and Z - C, CR6 and N, on condition that at least one of W or Y, or Z must be C; R6 -hydrogen halogen or C1-6alkyl; X - S and NR7; R7 - C1-6alkyl; and R8 - C1-6alkyl. Also described are method of obtaining compounds I, pharmaceutical composition and application of compounds, intermediate compounds, used in synthesis. ^ EFFECT: obtaining compounds which can be used to inhibit beta-amyloid formation and for treatment of Alzheimer's disease. ^ 48 cl, 5 tbl, 42 ex