NEW DERIVATIVES OF CYCLOUREA, PRODUCTION AND PHARMACEUTICAL APPLICATION AS KINASE INHIBITORS

FIELD: medicine; pharmacology. ^ SUBSTANCE: compounds of this invention possess properties of protein kinase inhibitors. In the general formula p means integer within 0 to 2; R and R1 mean O; A1 and A2 mean single bond, (C1-C6)alkyl; B2 means monocyclic or bicyclic, saturated or unsaturated heterocy...

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Hauptverfasser:	PATEK MARSEL, NAIR ANIL, LESJUISS DOMINIK, MOZHE ZHAK, SHTROBEL' KHARTMUT, RITTER KURT, NEMESEK KONSEPS'ON, FEJT TOMAS, ITTEHNZHER OGJUSTEHN, RUF SVEN, BENAR DID'E, AL'-OBEJDI FAKHAD, MALLERON ZHAN-LJUK, EHL'-AMAD JUSSEF, BUSHAR EHRVE, KHARLOU GREG, PALERMO MARK, BOND DEHNIEHL
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine; pharmacology. ^ SUBSTANCE: compounds of this invention possess properties of protein kinase inhibitors. In the general formula p means integer within 0 to 2; R and R1 mean O; A1 and A2 mean single bond, (C1-C6)alkyl; B2 means monocyclic or bicyclic, saturated or unsaturated heterocyclic radical including 1 to several identical or different heteroatoms, chosen among O, S, N and NR7, probably substituted with one or several identical or different substitutes. ^ EFFECT: inhibiting effect on protein kinase, effective application of compounds of formula for medical products. ^ 49 cl, 1 tbl, 6 dwg, 334 ex