TUBERCULAR VACCINES CONTAINING RECOMBINANT VCG STRAINS, EXPRESSING ALANINE DEHYDROGENASE, SERINE DEHYDRATASE AND-OR GLUTAMINE SYNTHASE
FIELD: medicine, microbiology. ^ SUBSTANCE: invention concerns live vaccine recombinant strain Mycobacterium bovis-BCG, containing the nucleic acid, capable to express and coding, at least, one fiber or a polypeptide which shows alanine dehydrogenase activity, glutamine synthase activity or serine h...
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| creator | LJU TSZJUN CHEHN' DZHEFFRI ALEKSANDER DEHVID |
| description | FIELD: medicine, microbiology. ^ SUBSTANCE: invention concerns live vaccine recombinant strain Mycobacterium bovis-BCG, containing the nucleic acid, capable to express and coding, at least, one fiber or a polypeptide which shows alanine dehydrogenase activity, glutamine synthase activity or serine hydratase activity. The corresponding amino-acid and nucleotide sequences are resulted in the description. The recombinant strain can contain all nucleic acid either its part, or the nucleic acid containing sequence, at least on 60 % identical sequence of the specified nucleic acid. The strain can be used for preparation of a pharmaceutical composition, in particular, vaccines or immunogene composition for treatment or prevention of a mammal against infection with micobacteria. The strain under the invention survives is better and is longer persists in an organism of the owner, inducing long protective immunity. ^ EFFECT: provision of more effective vaccines for prevention of tuberculosis and other infections caused by micobacteria. ^ 11 cl, 12 dwg, 2 tbl, 6 ex |
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The corresponding amino-acid and nucleotide sequences are resulted in the description. The recombinant strain can contain all nucleic acid either its part, or the nucleic acid containing sequence, at least on 60 % identical sequence of the specified nucleic acid. The strain can be used for preparation of a pharmaceutical composition, in particular, vaccines or immunogene composition for treatment or prevention of a mammal against infection with micobacteria. 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The corresponding amino-acid and nucleotide sequences are resulted in the description. The recombinant strain can contain all nucleic acid either its part, or the nucleic acid containing sequence, at least on 60 % identical sequence of the specified nucleic acid. The strain can be used for preparation of a pharmaceutical composition, in particular, vaccines or immunogene composition for treatment or prevention of a mammal against infection with micobacteria. The strain under the invention survives is better and is longer persists in an organism of the owner, inducing long protective immunity. ^ EFFECT: provision of more effective vaccines for prevention of tuberculosis and other infections caused by micobacteria. ^ 11 cl, 12 dwg, 2 tbl, 6 ex</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | TUBERCULAR VACCINES CONTAINING RECOMBINANT VCG STRAINS, EXPRESSING ALANINE DEHYDROGENASE, SERINE DEHYDRATASE AND-OR GLUTAMINE SYNTHASE |
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