TUBERCULAR VACCINES CONTAINING RECOMBINANT VCG STRAINS, EXPRESSING ALANINE DEHYDROGENASE, SERINE DEHYDRATASE AND-OR GLUTAMINE SYNTHASE

FIELD: medicine, microbiology. ^ SUBSTANCE: invention concerns live vaccine recombinant strain Mycobacterium bovis-BCG, containing the nucleic acid, capable to express and coding, at least, one fiber or a polypeptide which shows alanine dehydrogenase activity, glutamine synthase activity or serine hydratase activity. The corresponding amino-acid and nucleotide sequences are resulted in the description. The recombinant strain can contain all nucleic acid either its part, or the nucleic acid containing sequence, at least on 60 % identical sequence of the specified nucleic acid. The strain can be used for preparation of a pharmaceutical composition, in particular, vaccines or immunogene composition for treatment or prevention of a mammal against infection with micobacteria. The strain under the invention survives is better and is longer persists in an organism of the owner, inducing long protective immunity. ^ EFFECT: provision of more effective vaccines for prevention of tuberculosis and other infections caused by micobacteria. ^ 11 cl, 12 dwg, 2 tbl, 6 ex