METHOD FOR PRODUCTION OF MICRONISED POWDER OF INCAPSULATED ORGANIC DRUG SUBSTANCE WITH SLOW DISSOLUTION RATE

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: method consists in as follows: initial organic drug substance and auxiliary low-molecular organic ingredient, serving as a matrix to prolongate the release of the former substance into aqueous solution, are simultaneously and separately vaporised in rarefied neutral gas medium. The simultaneously obtained vapours of the mentioned substance and the matrix ingredient are then co-condensed on deposition surface. The angle between deposition velocity vectors of the mentioned drug substance and the matrix-forming ingredient, and inclination of the angle bisector to deposition surface are 5-170° and 10-90° respectively. Microcapsulation is effected or at positive temperatures of deposition surface during co-condensation process, or at negative temperatures of deposition surface during the co-condensate obtained warming to positive temperatures. ^ EFFECT: production of micronised powder of encapsulated organic drug substance with prolonged dissolution in aqueous medium during single-stage process. ^ 5 cl, 4 dwg, 5 ex