METHOD OF NON-SMALL CELL LUNG CARCINOMA DIAGNOSTICS AND RELATED ANALYSIS SET

FIELD: medicine; oncology; molecular biology. ^ SUBSTANCE: to diagnose non-small cell lung carcinoma potentially cancer-affected human tissue and adjacent histologically normal tissue are tested for gene WIF1 transcription level. Lowered transcription level detected in potentially cancer-affected hu...

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Hauptverfasser:	SVERDLOV EVGENIJ DAVIDOVICH, KOROBKO ELENA VLADIMIROVNA, VINOGRADOVA TAT'JANA VIKTOROVNA, ZBOROVSKAJA IRINA BORISOVNA, KOPANTSEV EVGENIJ PAVLOVICH, GEORGIEV GEORGIJ PAVLOVICH, KOROBKO IGOR' VIKTOROVICH, ZINOV'EVA MARINA VALER'EVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: medicine; oncology; molecular biology. ^ SUBSTANCE: to diagnose non-small cell lung carcinoma potentially cancer-affected human tissue and adjacent histologically normal tissue are tested for gene WIF1 transcription level. Lowered transcription level detected in potentially cancer-affected human tissue compared to that of adjacent histologically normal tissue is diagnostic indicator of non-small cell lung carcinoma. For realisation of polymerase chain reaction within detection of gene WIF1 transcription level, primers set of sequence SEQ ID NO: 1 and 2 is used. ^ EFFECT: invention application provides high-reliable diagnostics of non-small cell lung carcinoma, including squamous cell carcinoma, as well as at earliest stage of tumour transformation progression. ^ 8 cl, 2 dwg, 1 tbl, 6 ex