3-PHENYLCINNOLIN ANALOGUE AND BASED ON IT ANTI-TUMOR AGENT
FIELD: medicine; pharmacology. ^ SUBSTANCE: invention can be used in medicine and pharmaceutical industry and relates to the cell proliferation inhibitor and to the anti-tumor agent, which contains the 3-phenylcinnolin analogue as an active component, and has the formulas , where J presents the A-C-...
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Zusammenfassung: | FIELD: medicine; pharmacology. ^ SUBSTANCE: invention can be used in medicine and pharmaceutical industry and relates to the cell proliferation inhibitor and to the anti-tumor agent, which contains the 3-phenylcinnolin analogue as an active component, and has the formulas , where J presents the A-C-B, where C is carbon, A is alcoxy, OH, acyloxy or amino acid residue, B is hydrogen, alkyl group, carbonyl group or = N-NH2 together with A, K - (CH2)q; L - N-W, where N -nitrogen atom, or W-C-W', where C - carbon atom; W - alkyl group or hydrogen atom; W' - alkyl, phenyl, carboxyl or alcoxycarbonyl group or hydrogen; J-K-L-M corresponds to C(O-Y)=CH-C(W)=CH or M - group (CH2)m; Z - oxygen; X - alcoxyl group, halogenated alkyl group, nitrogroup, cyanogroup or halogen; X' - halogen or hydrogen; m and q = 1, n and n' = 0 or 1, and (n + n') less than 2. ^ EFFECT: improved anti-tumor agent is available based on described compound. ^ 82 ex |
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