NON-INFECTIOUS FOR HUMAN ADENOVIRUS AS VECTOR FOR SUBSTITUTION GENETIC THERAPY OF ANGIOGENESIS DISORDER PROVIDING EFFECTIVE SYNTHESIS OF HUMAN ANGIOGENIN IN MAMMALIAN TRANSFECTED CELLS, METHOD FOR ANGIOGENESIS INDUCTION, METHOD FOR TREATMENT OF ISCHEMIC DISEASE, COMPOSITION FOR INDUCTION OF ANGIOGENESIS AND TREATMENT OF ISCHEMIC DISEASE

FIELD: medicine, biotechnology, genetic engineering. ^ SUBSTANCE: invention proposes non-infectious for human adenovirus as a vector for substitution genetic therapy of angiogenesis disorders. This adenovirus is replicative-defect in mammalian cells (including humans) in region that is not essential...

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Hauptverfasser:	BOCHKOV NIKOLAJ PAVLOVICH, NARODITSKIJ BORIS SAVEL'EVICH, TARANTUL VJACHESLAV ZALMANOVICH, SVERDLOV EVGENIJ DAVIDOVICH, KONSTANTINOV BORIS ALEKSEEVICH, KHAJDAROVA NEHLLA VASIL'EVNA, GINTSBURG ALEKSANDR LEONIDOVICH, VORONOV DMITRIJ ALEKSANDROVICH, AVDEEVA SVETLANA VLADIMIROVNA, GAVRILENKO ALEKSANDR VASIL'EVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: medicine, biotechnology, genetic engineering. ^ SUBSTANCE: invention proposes non-infectious for human adenovirus as a vector for substitution genetic therapy of angiogenesis disorders. This adenovirus is replicative-defect in mammalian cells (including humans) in region that is not essential for replication in avian cells and carries expression cassette consisting of cytomegalovirus promoter, human angiogenin gene cDNA and polyadenylation signal of bovine hormone growth, and provides induction of angiogenesis. Invention proposes a method for induction of angiogenesis and method for treatment of ischemic disease by using a composition comprising the proposed recombinant adenovirus. Invention can be used in medicine in treatment of cardiovascular diseases. ^ EFFECT: valuable medicinal properties of adenovirus and composition. ^ 5 cl, 1 dwg, 4 ex