NONHYGROSCOPIC CRYSTALLINE 5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[(2S)-2-HYDROXY-3-MORPHOLIN-4-YLPROPYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALEATE SALT, PHARMACEUTICAL COMPOSITION AND METHOD FOR CANCER TREATMENT

FIELD: organic chemistry, medicine, oncology, pharmacy. ^ SUBSTANCE: invention relates to nonhygroscopic crystalline 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,2-dimethyl-1H-pyrrol-3-carboxamide maleate salt that possesses inhibitory eff...

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Hauptverfasser:	SONG DONG, LU TSJUN, MOREJDZHIS MAJKL EHNTONI, TSZIN' TSINVU, BLASKO ANDREJ, VONDERVELL BRENDA S'JU
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine, oncology, pharmacy. ^ SUBSTANCE: invention relates to nonhygroscopic crystalline 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,2-dimethyl-1H-pyrrol-3-carboxamide maleate salt that possesses inhibitory effect on tyrosine kinase receptors. Also, invention relates to a pharmaceutical composition and to a method for treatment of cancer in mammals using such compositions. ^ EFFECT: valuable medicinal property of compound and pharmaceutical composition. ^ 12 cl, 12 tbl, 17 dwg, 5 ex