PARTIAL AND COMPLETE AGONISTS OF ADENOSINE A1 RECEPTORS

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel compounds that are partial and complete agonists of adenosine A1 receptors of the formula (1): wherein R1 means cyclopentyl, cyclohexyl or tetrahydrofuranyl optionally substituted with hydroxy-group or -CO2CH2CH3; R2 means hydrogen atom; R3 means phenyl, isoxazole, thiophenyl or thiazolyl substituted optionally with one or more substitutes chosen from group comprising methyl, methoxy- group, fluorine atom and chlorine atom; R4 and R5 mean hydrogen atom; T means a covalent bond or methylene group; X means covalent bond; Y means -O-, -NH- or covalent bond; Z means alkylene group comprising of 1-3 carbon atoms. Proposed compounds can be used in treatment of different morbid states, in particular, tachycardia and atrium tremor, stenocardia, myocardium infarction and hyperlipidemia, and to a pharmaceutical composition based on these compounds. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 22 cl, 16 ex