RECOMBINANT THERMOSTABLE FORMATE DEHYDROGENASE

RECOMBINANT THERMOSTABLE FORMATE DEHYDROGENASE

FIELD: biotechnology, biochemistry, enzymes. ^ SUBSTANCE: invention represents a recombinant formate dehydrogenase showing amino acid sequence that corresponds to amino acid sequence of formate dehydrogenase of wild type and containing glutamic acid residue at position corresponding to position 106...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TISHKOV VLADIMIR IVANOVICH, SAVIN SVJATOSLAV SERGEEVICH, SAVINA LARISA IVANOVNA, FEDORCHUK VLADIMIR VITAL'EVICH
Format: Patent
Sprache:eng ; rus
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:FIELD: biotechnology, biochemistry, enzymes. ^ SUBSTANCE: invention represents a recombinant formate dehydrogenase showing amino acid sequence that corresponds to amino acid sequence of formate dehydrogenase of wild type and containing glutamic acid residue at position corresponding to position 106 in amino acid sequence of formate dehydrogenase from Mycobacterium vaccae N10 wherein glutamic acid residue is replaced for arginine residue. This substitution can be used in combination with other mutations providing acquiring novel and/or improved properties in formate dehydrogenases. Invention provides preparing novel formate dehydrogenase that possesses the enhanced stability as compared with other enzymes. ^ EFFECT: improved and valuable biochemical property of enzyme. ^ 4 cl, 2 tbl, 5 ex