4-OXO-1-(3-SUBSTITUTED PHENYL)-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, METHOD FOR TREATMENT AND PROPHYLAXIS AND METHOD FOR IMPROVING COGNITIVE ABILITY IN HEALTH SUBJECT

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention describes novel 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamides of the general formula (I): or their pharmaceutically acceptable salts wherein Ar means phenyl or thienyl; Y means -COOH, (C1-C6)-alkyl, (C1-C4-alkyl)n-COOH, (C3-C4)-cycloalkyl-COOH wherein (C1-C6)-alkyl and (C3-C4)-cycloalkyl are optionally substituted with halogen atom, hydroxy-group, -CN, and (C1-C4)-alkyl-substitutes are bound optionally to form (C3-C4)-cycloalkyl and wherein n = 0, 1, 2, 3 or 4; R means hydrogen atom (H) or (C1-C6)-alkyl; R1 means H, (C1-C6)-alkyl optionally substituted with halogen atom; (C3-C6)-cycloalkyl optionally substituted with halogen atom, (C1-C6)-alkyl, -OH, -CN or phenyl; (C1-C6-alkyl)-SOp-(C1-C6)-alkyl wherein p = 0, 1 or 2; or 1,3,4-thiadiazolyl substituted with halogen-(C1-C6)-alkyl; or R1 means methyl substituted with cyclopropyl; R2 means H, halogen atom or (C1-C6)-alkyl; R3 means H or halogen atom, and pharmaceutical compositions based on thereof. Compounds possess inhibitory activity and can be used in treatment of asthma and inflammatory diseases. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved method of treatment. ^ 22 cl, 4 tbl, 30 ex