COMBINED CELL TRANSPLANT BASED ON LYMPHOKINE-ACTIVATED KILLERS AND DENDRITE CELLS, METHOD FOR PRODUCTION THEREOF AND METHOD FOR TREATMENT AND PROPHYLAXIS OF MALIGNANT, INFECTIVE DISEASES AND IMMUNODEFICIENT CONDITIONS

FIELD: biopharmacology and medicine. ^ SUBSTANCE: disclosed is method for production of mononuclear blood cells, namely activated lymphocytes (ACL) and dendrite cells (DC). Claimed method includes a) isolation of mononuclear leucocytes (MNL) from blood and marrow of patient suffering from malignant neoplasm, or infective disease, or immunodeficient condition; d) incubation of isolated mononuclear lymphocytes in cultural medium; c) separation of MNL cultural bottles adhering to plastic and non-adhering thereto.; d) treatment of adhering MNL with growth factors to produce dendrite cells therefrom; e) treatment of DC with lysates from patient tumor; f) cultivation of non-adhered lymphocytes with interleukine-2 to produce ACL-cells. Also disclosed is method for treatment and prophylaxis malignant and infective diseases and immunodeficient conditions in patients by combined application of ACL-cells and dendrite cells. ^ EFFECT: new method for treatment and prophylaxis of malignant, infective diseases and immunodeficient conditions. ^ 3 cl