CHIRAL DERIVATIVES OF OXAZOLARYLPROPIONIC ACID AND THEIR USING AS AGONISTS OR RECEPTOR ACTIVATED BY PEROXISOME PROLIFERATOR (PPAR AGONISTS)

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel compounds of the formula (I) and their pharmaceutically acceptable salts and/or pharmaceutically acceptable esters. Proposed compounds possess properties of agonists of receptors activated by peroxisome proliferators (PPAR agonists) and can be used in treatment of such diseases as diabetes mellitus, hypertension, atherosclerotic diseases and others. In the general formula (I) R1 represents phenyl, optionally mono-, di- or tri-substituted with halogen atom, lower alkyl, fluorine-lower alkyl, lower alkoxy-group; R2 represents hydrogen atom or lower alkyl; R3 and R4 represents independently of one another hydrogen atom, hydroxy-group, halogen atom, lower alkyl, fluorine-(lower alkyl), lower alkoxy-group wherein at least one of radicals R3 and R4 doesn't represent hydrogen atom; R5 represents lower alkoxy-group; R6 represents hydrogen atom or lower alkyl; n = 1. Also, invention relates to a pharmaceutical composition based on compounds of the invention. ^ EFFECT: valuable medicinal properties of compounds. ^ 19 cl, 1 tbl, 7 sch, 56 ex