METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF INDAPAMIDE AND RESVERATROL AT L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE

FIELD: medicine, experimental cardiopharmacology. ^ SUBSTANCE: it is necessary to model endothelial dysfunction due to daily intraperitoneal injection of L-nitro-arginine-methyl ether (L-NAME) for rats during 7 d at the dosage of 25 mg/kg. At the background of modeling the dysfunction one should per...

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Hauptverfasser:	STANKOVICH MILENA, GLADCHENKO MIKHAIL PETROVICH, KOCHKAROV VLADIMIR ISKHAKOVICH, ARTJUSHKOVA ELENA BORISOVNA, NOSOV ALEKSANDR MIKHAJLOVICH, SMIRNOVA OKSANA JUR'EVNA, AFANAS'EV JURIJ IVANOVICH, ZHILJAKOVA ELENA TEODOROVNA, PROKHODA EVGENIJ FEDOROVICH, POKROVSKIJ MIKHAIL VLADIMIROVICH, NOVIKOV OLEG OLEGOVICH, TATARENKOVA IRINA ALEKSANDROVNA, PONAR'IN ALEKSEJ NIKOLAEVICH, VASIL'EV GEORGIJ VLADIMIROVICH, KOROKIN MIKHAIL VIKTOROVICH, PASHIN EVGENIJ NIKOLAEVICH, POKROVSKAJA TAT'JANA GRIGOR'EVNA, NOVIKOVA VIKTORIJA ALEKSANDROVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: medicine, experimental cardiopharmacology. ^ SUBSTANCE: it is necessary to model endothelial dysfunction due to daily intraperitoneal injection of L-nitro-arginine-methyl ether (L-NAME) for rats during 7 d at the dosage of 25 mg/kg. At the background of modeling the dysfunction one should perform its correction due to simultaneous injection of indapamide intragastrally at the dosage of 2 mg/kg and resveratrol intraperitoneally at the dosage of 2 mg/kg once daily. The innovation provides efficient correction of endothelial dysfunction induced by inhibiting NO synthase due to combined injection of indapamide and resveratrol. ^ EFFECT: higher efficiency of correction. ^ 1 ex, 2 tbl