METHOD FOR PREPARING HEPARINS OF LOW MOLECULAR MASS

FIELD: medicine, biochemical technology. ^ SUBSTANCE: invention proposes a method for preparing low-molecular heparins using enzymatic cleavage. For enzymatic depolymerization the method involves using papain, chymotrypsin or complexes of hydrolases as components of preparations "Protease C&quo...

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Hauptverfasser:	TIKHONOV VLADIMIR EVGEN'EVICH, VARLAMOV VALERIJ PETROVICH, MAKAROV VLADIMIR ALEKSANDROVICH, DROZD NATAL'JA NIKOLAEVNA, SKRJABIN KONSTANTIN GEORGIEVICH, BANNIKOVA GALINA EVGEN'EVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	FIELD: medicine, biochemical technology. ^ SUBSTANCE: invention proposes a method for preparing low-molecular heparins using enzymatic cleavage. For enzymatic depolymerization the method involves using papain, chymotrypsin or complexes of hydrolases as components of preparations "Protease C" and celloviridine immobilized on silochrome or polyvinyl alcohol. Method provides preparing low-molecular heparins by effect of immobilized hydrolases with the yield of the end product about 70-80%. ^ EFFECT: improved preparing method. ^ 8 ex