INDOLE DERIVATIVES SHOWING AFFINITY TO 5-HT6 RECEPTORS

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel derivatives of indole of the general formula (I): wherein R1 means -S(O)0-2-A wherein A means phenyl optionally substituted with one or some groups or some groups chosen from (lower)-alkyl, (lower)-alkoxy-group, ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	FISHER LORENS EHMERSON, BEHRD KOLIN CHARLZ, KLARK ROBIN DUGLAS, REPKE DEJVID BRJUS, KHARRIS III RAL'F N'JU
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel derivatives of indole of the general formula (I): wherein R1 means -S(O)0-2-A wherein A means phenyl optionally substituted with one or some groups or some groups chosen from (lower)-alkyl, (lower)-alkoxy-group, halogen atom, (lower)-halogenalkyl, (lower)-alkylsulfonyl or (lower)-halogenalkylsulfonyl, naphthyl, pyridinyl or benzothiazolyl; R2 means hydrogen atom, (C1-C6)-alkyl; R3 means hydrogen atom, (C1-C6)-alkyl; R4 means hydrogen atom, or one radical among R5, R6 or R7 means group of the general formula (B) wherein W means group -CH- or nitrogen atom, and others mean independently hydrogen atom; R8 means hydrogen atom, (C1-C10)-alkyl; R9 and R10 mean independently hydrogen atom, or their pharmaceutically acceptable salts. Compounds of the formula (I) possess affinity to 5-HT6 receptors that allows their using in pharmaceutical composition. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 20 cl, 14 ex