SUBSTITUTED BENZOPYRANE DERIVATIVES USED AGAINST ARRHYTHMIA

FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to derivatives of benzopyrane of the formula (1) ^ or the formula (2) , ^ wherein each R1 and R2 means independently of one another hydrogen atom; R3 means hydroxyl group; R4 means hydrogen atom; R5 means (C1-C6)-alkyl group substituted with (C6-C14)-aryl group wherein indicated (C1-C6)-group can be substituted optionally with hydroxyl, methyl group and indicated (C6-C14)-aryl group can be substitute optionally with 1-3 radicals R7 (wherein R7 represents halogen atom or amino-group) or linear (C5-C8)-alkyl group; R6 means (C1-C6)-alkyl group (wherein indicated alkyl group can be substituted optionally with hydroxyl or amino-group), halogen atom, nitro-group or -C(O)NH2 but excluding compound of the formula (1) wherein R means -NO2 at position 6; R5 means -CH2CH2Ph, and R1 and R2 mean methyl group, and compound of the formula (1) wherein R6 means bromine atom at position 6; R5 means benzyl and R1 and R2 mean methyl group, or their pharmaceutically acceptable salts, and a pharmaceutical preparation based on thereof. Proposed compounds are useful as anti-arrhythmic agents. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 8 cl, 7 tbl, 26 ex