DERIVATIVES OF AROMATIC DICARBOXYLIC ACIDS

FIELD: organic chemistry, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to derivatives of aromatic dicarboxylic acids of the general formula (I): ^ wherein means thiophene ring that can be unsubstituted or substituted with 1 or 2 substitutes; R1 and R2 are similar or different and mean hydr...

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Bibliographische Detailangaben
Hauptverfasser:	LEZER-RAJFF UL'RIKE, TSIMMERMANN GERD, ZATTEL'KAU TIM
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to derivatives of aromatic dicarboxylic acids of the general formula (I): ^ wherein means thiophene ring that can be unsubstituted or substituted with 1 or 2 substitutes; R1 and R2 are similar or different and mean hydrogen atom, branched or unbranched (C1-C14)-alkyl group that can be unsubstituted or substituted with one or some substitutes, carbocyclic group or heterocyclic group; R1 and R2 form in common with nitrogen atom 3-6-membered cycle, and to their enantiomers, diastereoisomers, racemates and their physiologically acceptable salts. Compounds possess inhibitory effect with respect to activity of histon deacetylase. Also, invention describes a medicinal agent based on compounds of the formula (I). ^ EFFECT: valuable medicinal and biochemical properties of derivatives. ^ 6 cl, 1 tbl, 18 ex