METHOD FOR PREDICTING EFFICIENCY OF INTERFERONOTHERAPY AT CHRONIC HEPATITIS B

FIELD: medicine, gastroenterology. ^ SUBSTANCE: one should detect TNF-alpha content in blood serum and IFN-gamma synthesis by mononuclear cells in vitro before and 4.5 h after the first injection of interferon-preparation for a patient. At detecting TNF-alpha content in blood serum before injection not exceeding 59.31 pg/ml, and at the increase of TNF-alpha level after the first injection of interferon- being above 46.1 % and IFN-gamma synthesis being above 70.25% against initial data one should predict high efficiency of interferonotherapy in the course of a 6-mo-long interferonotherapy. At TNF-alpha content in blood serum being above 74.51 pg/ml and increased TNF-alpha values not more than 24.9%, and IFN-gamma - not more than 70% or their decrease after the first injection of interferon- it is possible to predict the absence of virological response, that is insufficient efficiency of interferonotherapy. Application of the method suggested enables to predict the results of interferonotherapy in case of chronic viral hepatitis B just after the first injection of interferon- preparation. ^ EFFECT: higher efficiency of prediction. ^ 2 ex, 1 tbl