MERCAPTOACETYLAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, METHOD FOR PRODUCTION THEREOF AND METHOD FOR TREATMENT OF CARDIOVASCULAR CONDITION

FIELD: pharmacology, medicine. ^ SUBSTANCE: invention relates to new mercaptoacetylamide derivatives, which represents angiotensine converting enzyme and neutral endopeptidase inhibitors and useful in treatment of cardiovascular condition. More particularly invention relates to derivatives of formul...

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Bibliographische Detailangaben
Hauptverfasser:	ZOJRING BERNKHARD, KLEEMANN KHAJNTS-VERNER, KEL' DZHEK RODZHER, FLINN GARI A, JABLONKA BERND, GERKEN MANFRED, LINTS VOL'FGANG, ANDERSON BARBARA EHNN, MEKHDI SHUDZHAAT, ZAJTS VERNER
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: pharmacology, medicine. ^ SUBSTANCE: invention relates to new mercaptoacetylamide derivatives, which represents angiotensine converting enzyme and neutral endopeptidase inhibitors and useful in treatment of cardiovascular condition. More particularly invention relates to derivatives of formula I , wherein R1 represents hydrogen or acyl; wherein R2 represents hydrogen or biphenylmethyl; { represents -(CH2)n (n = 1, integer); B1 and B2 are independently hydrogen; or pharmaceutically acceptable salts or stereomers thereof. Method for production of compounds of formula I and formula II, pharmaceutical composition on the base of formula I, method for production thereof and method for treatment of cardiovascular condition. ^ EFFECT: new derivatives having value biological properties. ^ 14 cl, 3 tbl, 4 ex, 1 dwg