METHOD FOR PREPARING 3,6-DIAZAHOMOADAMANTANE

FIELD: organic chemistry, chemical technology, virology. ^ SUBSTANCE: invention relates to a new method for synthesis of a novel compound - 3,6-diazahomoadamantane of the formula: . Compounds of 3,6-diazahomoadamantane class possess an antiviral effect comparable with antiviral effect of aminoadaman...

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Hauptverfasser: AZZHEUROVA IRINA ANATOL'EVNA, KUZNETSOV ANATOLIJ IVANOVICH
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: organic chemistry, chemical technology, virology. ^ SUBSTANCE: invention relates to a new method for synthesis of a novel compound - 3,6-diazahomoadamantane of the formula: . Compounds of 3,6-diazahomoadamantane class possess an antiviral effect comparable with antiviral effect of aminoadamantane, elicit strychnine-like activity and show bactericidal, fungicide and algicidal properties and can be used as an antiviral preparation. Method for synthesis of 3,6-diazahomoadamantane involves interaction of 1-phenylthio-3,6-diazahomoadamantane-9-one with 65-66% hydrazine hydrate at boiling to form 1-phenylthio-3,6-diazahomoadamantane-9-one hydrazone that is subjected for reduction in Kizhner-Wolf reaction by alloying with alkali and then 1-phenylthio-3,6-diazahomoadamantane is desulfurized with Raney nickel in isopropyl alcohol at boiling. ^ EFFECT: improved method of synthesis. ^ 2 cl, 1 ex