METHOD FOR PREPARING MODIFIED GLYCOSAMINOGLYCANS POSSESSING ANALGESIC PROPERTY

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for preparing modified glycosaminoglycans possessing analgesic properties. Method involves interaction of glycosaminoglycans with 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminoantipyrine) in aqueous medium...

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Hauptverfasser:	SIBAGATULLIN NUR GASYMOVICH, PONEDEL'KINA IRINA JUR'EVNA, LUKINA ELENA SERGEEVNA, SUFIJAROVA ROZA SHAJKHAL'NUROVNA, PARFENOVA TAMARA IL'INICHNA, ODINOKOV VIKTOR NIKOLAEVICH, BASHKATOV SERGEJ ALEKSANDROVICH, DZHEMILEV USEIN MEMETOVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for preparing modified glycosaminoglycans possessing analgesic properties. Method involves interaction of glycosaminoglycans with 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminoantipyrine) in aqueous medium at pH = 4.7-4.8 in the presence water-soluble 1-ethyl-3-[3-(dimethlamino)propyl]carbodiimide as a condensing agent at room temperature followed by purification from low-molecular reagents. Method involves a single step that simplifies technology in preparing modified glycosaminoglycans. ^ EFFECT: improved preparing method. ^ 3 ex