PHOTOSENSITIZING AGENTS FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

FIELD: medicine, in particular photosensitizing agents for antimicrobial photodynamic therapy. ^ SUBSTANCE: invention relates to new photosensitizing agents for antimicrobial photodynamic therapy namely cationic phthalocyanines of general formula MPc(CH2X)nCln, wherein Pc is phthalocyanine rest C32H...

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Hauptverfasser:	SLIVKA LJUDMILA KONSTANTINOVNA, STRAKHOVSKAJA MARINA GLEBOVNA, KALIJA OLEG LEONIDOVICH, KUZNETSOVA NINA ALEKSANDROVNA, NEGRIMOVSKIJ VLADIMIR MIKHAJLOVICH, LUK'JANETS EVGENIJ ANTONOVICH, LUZHKOV JURIJ MIKHAJLOVICH, KUCHEROV ALEKSANDR GEORGIEVICH, JUZHAKOVA OL'GA ALEKSEEVNA, JAKUBOVSKAJA RAISA IVANOVNA, VOROZHTSOV GEORGIJ NIKOLAEVICH, LAPCHENKO ALEKSANDR SERGEEVICH, KUZ'MIN SERGEJ GEORGIEVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ADHESIVES CHEMISTRY DYES HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE LAKES MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS NATURAL RESINS ORGANIC CHEMISTRY ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: medicine, in particular photosensitizing agents for antimicrobial photodynamic therapy. ^ SUBSTANCE: invention relates to new photosensitizing agents for antimicrobial photodynamic therapy namely cationic phthalocyanines of general formula MPc(CH2X)nCln, wherein Pc is phthalocyanine rest C32H16N8; M is Zn, AlY; n = 6-8; X is Y is Cl, OH, OSO3H. Claimed agents is characterized by wide range of antimicrobial activity. Single complex action of nontoxic in darkness micromolar (up to 2.0 muM) concentration thereof and low dose of red irradiation make it possible to produce high inactivation levels (up to 97-99 %) both gram-negative bacteria and yeast fungi of genus Candida. ^ EFFECT: improved agents for treatment of various severe complications of inflammation diseases. ^ 3 dwg, 13 ex, 2 tbl