METHOD FOR STABLE CELL TRANSDUCTION BY VIRAL VECTORS

FIELD: biotechnology. ^ SUBSTANCE: invention relates to method for stable cell transduction of hematopoesis system or hematopoesis stem cells. Claimed method includes simultaneous cell in vivo or in vitro contact with lentivirus vector and molecule bonding to cell surface. Method of present inventio...

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Bibliographische Detailangaben
Hauptverfasser:	JUMO LORAN, DEHVIS BRAJAN, DROPULIK BORO, LESHER MISHELL, KHAN VEJ, SLEPUSHKIN VLADIMIR, CHANG JUNG-NIEN, LU KSIAOBIN
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology. ^ SUBSTANCE: invention relates to method for stable cell transduction of hematopoesis system or hematopoesis stem cells. Claimed method includes simultaneous cell in vivo or in vitro contact with lentivirus vector and molecule bonding to cell surface. Method of present invention allows stable transduction more 75 % of cells over 14 days. Method for introduction of gene material into cell also is disclosed. ^ EFFECT: new method useful in medicine, virology, and gene engineering. ^ 40 cl, 28 dwg, 9 ex