METHOD FOR DETERMINING BLOOD OXYMETHYL URACYL

FIELD: medicine. ^ SUBSTANCE: method involves making extraction with dimethyl sulfoxide mixed with water in 3:1 proportion in retort having backflow condenser on water bath during 1 h. The produced extract is filtered. The filtrate is chromatographically studied first in 5 cm high and 0.7 cm diamete...

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Hauptverfasser:	SHIKOV ARTEM NIKOLAEVICH, SHIKOVA JULIJA VITAL'EVNA, ELOVA ELENA VLADIMIROVNA, CHERNOV NIKOLAJ VASIL'EVICH, TIMERBULATOV VIL' MAMILOVICH, BRAZHENKO MIKHAIL ALEKSANDROVICH, GOLOVASTIKOVA ZHANNA MIKHAJLOVNA, PLECHEVA DINA VLADIMIROVNA, LIKHODED VITALIJ ALEKSEEVICH, PLECHEV VLADIMIR VJACHESLAVOVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	FIELD: medicine. ^ SUBSTANCE: method involves making extraction with dimethyl sulfoxide mixed with water in 3:1 proportion in retort having backflow condenser on water bath during 1 h. The produced extract is filtered. The filtrate is chromatographically studied first in 5 cm high and 0.7 cm diameter columns with alumina and then in thin sorbent layer solvent system containing condensed ammonium and alcohol taken in 1:4 proportion. The eluate is subjected to spectrophotometric analysis at 278±2 nm. Oxymethyl uracyl quantity is determined from formula C=D x b/(E1% cvxa), where C is the substance concentration in %, D is the optical density, b is the dilution rate, E1% cv is the specific absorption index, a is the exact weighing in g. ^ EFFECT: high accuracy of blood oxymethyl uracyl control in treatment course.