EMULSION INACTIVATED VACCINE AGAINST INFECTIVE CATTLE RINOTRACHEITIS

FIELD: veterinary virology and biotechnology. ^ SUBSTANCE: claimed vaccine contains antigen material from infective cattle rinotracheitis virus strain, reproduced in specific passage cell cultures having biological activity of at least 6.0 lg TCD50/cm3 and inactivated with aminoethyl ethyleneimine,...

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Bibliographische Detailangaben
Hauptverfasser:	GETMANSKIJ OLEG IVANOVICH, RUCHNOV JURIJ EVGEN'EVICH, KOSTYRKIN JURIJ ALEKSEEVICH, NIKESHINA TAT'JANA BORISOVNA, ZHBANOVA TAT'JANA VALENTINOVNA, MISHCHENKO VLADIMIR ALEKSANDROVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: veterinary virology and biotechnology. ^ SUBSTANCE: claimed vaccine contains antigen material from infective cattle rinotracheitis virus strain, reproduced in specific passage cell cultures having biological activity of at least 6.0 lg TCD50/cm3 and inactivated with aminoethyl ethyleneimine, and oily adjuvant in mass ratio of 30.0:70.0, respectively. Aforementioned virus strain is reproduced in specific passage cell cultures and has cytopathic action and during incubation for 48-96 h in accumulated in titer of 6.5-8.0 lg TCD50/cm3. Aminoethyl ethyleneimine is used in concentration of 0.1-0.2 % followed by neutralization thereof with sodium thiosulfate. ^ EFFECT: vaccine with high antigenic and immunogenic activity and safety; enhanced assortment of specific agents for infective cattle rinotracheitis prophylaxis. ^ 15 cl, 6 tbl, 7 ex