DERIVATIVES OF 2-IMINOPYRROLIDINE

FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention proposes derivatives of 2-iminopyrrolidine of the general formula (I) given in the invention description, their salts and pharmaceutical compositions possessing antagonistic effect on thrombin receptors. Substitutes A, R101, R102, R103, R5,...

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Hauptverfasser:	KOGUSI MOTODZI, KAMADA ATSUSI, ITO OSAMU, KHISINUMA IEKHARU, ONO NAOTO, KAVATA TSUTOMU, TERAUTI TARO, MIJAZAVA SIUKHEI, SATO NOBUAKI, TSUKADA ITARU, OKANO KAZUO, KOTAKE MAKOTO, MATSUOKA TOSIJUKI, MUSA TAKASI, OOKHASI ESIAKI, KADZIVARA AKIKHARU, MATSUURA FUMIESI, SUZUKI SUITI, KIMURA AKIFUMI, TANAKA KHIROSI, KAVAKHARA TETSUJA, KLARK RICHARD, NAOE ESIMITSU, KOBAJASI KHIROKO, MIJAMOTO MITSUAKI, TIBA KEN-ITI, SINODA MASANOBU, OZAKI FUMIKHIRO
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention proposes derivatives of 2-iminopyrrolidine of the general formula (I) given in the invention description, their salts and pharmaceutical compositions possessing antagonistic effect on thrombin receptors. Substitutes A, R101, R102, R103, R5, R6, Y1, Y2, ring B and Ar are determined in the invention claim. Invention provides using derivatives of 2-iminopyrrolidine that elicit the excellent effect in therapy or prophylaxis of thrombin-associated diseases. ^ EFFECT: valuable medicinal properties of compounds. ^ 37 cl, 3 dwg, 4 tbl, 2428 ex