METHOD FOR PRODUCTION OF 2-CHLORO-4-NITROPHENOL

METHOD FOR PRODUCTION OF 2-CHLORO-4-NITROPHENOL

FIELD: biochemistry, in particular preparation of chloro-substituted nitrophenol. ^ SUBSTANCE: claimed method includes oxidative chlorination of 4-nitrophenol with mixture of hydrochloric acid and 19-33 % hydrogen peroxide in 30-60 % sulfuric acid medium. Molar ratio of 4-nitrophenol/oxiding agent i...

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Hauptverfasser: ZADOV VLADIMIR EFIMOVICH, SUBOCH GEORGIJ ANATOL'EVICH, SKOBELEV VALERIJ VIKTOROVICH, BINDAROVICH OLEG VLADISLAVOVICH
Format: Patent
Sprache:eng ; rus
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:FIELD: biochemistry, in particular preparation of chloro-substituted nitrophenol. ^ SUBSTANCE: claimed method includes oxidative chlorination of 4-nitrophenol with mixture of hydrochloric acid and 19-33 % hydrogen peroxide in 30-60 % sulfuric acid medium. Molar ratio of 4-nitrophenol/oxiding agent is 1:1. Obtained product precipitate is filtered and washed with cold water. Preparations of present invention are useful as active ingredient for antifungal drugs in skin lesions. ^ EFFECT: improved method; increased yield of target product. ^ 1 ex