METHOD FOR PRODUCTION OF ANTIGEN AGGREGATES AND USES THEREOF IN PHARMACEUTICALS

FIELD: medicine. ^ SUBSTANCE: disclosed are aggregate antigen construct, method for production thereof, vaccine preparation containing the same, and uses thereof. Antigen aggregated construct having size of 30-500 nm improves immunogenicity of target preparation and differential recognition by immun...

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Hauptverfasser:	SEVER MENS'ES MINERVA, MUSIO GONSALES VENERA LUSILA, GIL'EN N'ETO KHERARDO EHNRIKE, AGILAR RUBIDO KHULIO SESAR, PENTON ARIAS EHDUARDO, TAMBARA EHRNANDES JANET, FAL'KON KAMA VIVIANA, KRUS RIKONDO LUIS KHAV'ER, TLEUGABULOVA DINA, SIMON BERNAR ILOKI ASSANGA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine. ^ SUBSTANCE: disclosed are aggregate antigen construct, method for production thereof, vaccine preparation containing the same, and uses thereof. Antigen aggregated construct having size of 30-500 nm improves immunogenicity of target preparation and differential recognition by immune system. Method for production claimed construct includes selection of necessary antigen, addition of said antigen into medium advancing to aggregation process, mixture incubation for 24 hours-7 days at 28°C and collection of aggregate particle having size form 30 to 500 nm for example by gel filtration, ultrafiltration or dialysis. Invention is useful in vaccine production. ^ EFFECT: antigens with increased immunogenicity. ^ 33 cl, 19 dwg, 1 tbl, 10 ex