SUBSTITUTED DERIVATIVES OF N-BENZYLINDOL-3-YL-GLYOXYLIC ACID POSSESSING ANTITUMOR EFFECT (VARIANTS), THEIR ACID-ADDITIVE SALTS (VARIANTS), PHARMACEUTICAL PREPARATION, PHARMACEUTICAL FORMULATION

FIELD: organic chemistry, medicine, oncology, pharmacy. ^ SUBSTANCE: invention relates to substituted derivatives of N-benzylindol-3-yl-glyoxylic acid of the formula (1): wherein groups R, R1, R2, R3, R4 and Z have the following values: R means -NO2, -NH2, (C1-C6)-acylamino-, aroylamino-, nicotinoyl or isonicotinoyl, arylsulfonylamino-, succinimido- wherein this residue R can be substituted with (C1-C6)-group by choosing by carbon atom at positions 2, 3 and 4 of phenyl ring; R1 means hydrogen atom (H), (C1-C6)-alkyl that can be replaced with at least one phenyl group; R2 means pyridyl; R3 and R4 mean H; Z means oxygen (O), sulfur (S) atom. Compounds of the formula (1) possess an antitumor effect that allows their using in pharmaceutical compositions. ^ EFFECT: valuable medicinal properties of compounds and compositions. ^ 6 cl, 2 dwg, 3 tbl, 9 ex